Table 1.
Demographic and Clinical Characteristics of Adults With NAFLD in the TARGET‐NASH Cohort
| Patient Attribute | Severity of Liver Disease* | All Participants (n = 3,474) | P Value | ||
|---|---|---|---|---|---|
| NAFL (n = 1,052 [30.2%]) | NASH (n = 1,293 [37.2%]) | NAFLD Cirrhosis (n = 1,129 [32.5%]) | |||
| Age at study entry (years) | |||||
| Median (n) | 58.0 (1,051) | 56.0 (1,293) | 62.0 (1,129) | 59.0 (3,473) | <0.0001 |
| Mean (SD) | 56.8 (13.6) | 53.4 (13.8) | 61.1 (9.8) | 56.9 (13.0) | |
| Sex, n (%) | |||||
| Female | 557 (52.9) | 826 (63.9) | 664 (58.8) | 2,047 (58.9) | <0.0001 |
| Race, n (%) | |||||
| White | 617 (58.7) | 965 (74.6) | 1,006 (89.1) | 2,588 (74.5) | <0.0001 |
| Black or African American | 74 (7.0) | 88 (6.8) | 21 (1.9) | 183 (5.3) | |
| Asian | 266 (25.3) | 130 (10.1) | 30 (2.7) | 426 (12.3) | |
| Ethnicity, n (%) | |||||
| Hispanic or Latino | 121 (11.5) | 166 (12.8) | 139 (12.3) | 426 (12.3) | 0.35 |
| Not Hispanic or Latino | 881 (83.8) | 1,078 (83.4) | 956 (84.6) | 2,915 (84.0) | |
| BMI (kg/m2) at enrollment † | |||||
| Median (n) | 29.0 (1017) | 33.0 (1270) | 34.0 (1107) | 32.0 (3394) | <0.0001 |
| Mean (SD) | 30.9 (7.3) | 33.9 (7.4) | 34.7 (7.5) | 33.3 (7.6) | |
| Diabetes, n (%) | |||||
| Yes | 333 (31.7) | 605 (46.8) | 811 (71.8) | 1,749 (50.3) | <0.0001 |
| Hypertension, n (%) | |||||
| Yes | 618 (58.7) | 840 (65.0) | 983 (87.1) | 2,441 (70.3) | <0.0001 |
| Hyperlipidemia, n (%) | |||||
| Yes | 542 (51.5) | 873 (67.5) | 719 (63.7) | 2,134 (61.4) | <0.0001 |
| Cardiovascular disease, n (%) | |||||
| Yes | 162 (15.4) | 201 (15.5 | 280 (24.8) | 643 (18.5) | <0.0001 |
| Mental health diagnosis, n (%) | |||||
| Yes | 404 (38.4) | 644 (49.8) | 655 (58.0) | 1,703 (49.0) | <0.0001 |
| Osteoarthritis, n (%) | |||||
| Yes | 65 (6.2) | 135 (10.4) | 156 (13.8) | 356 (10.2) | <0.0001 |
| Autoimmune/rheumatologic, n (%) | |||||
| Yes | 58 (5.5) | 101 (7.8) | 79 (7.0) | 238 (6.9) | 0.09 |
| ≥1 abdominal imaging study ‡ | 777 (73.9) | 1,176 (91.0) | 1,074 (95.1) | 3,027 (87.1) | <0.0001 |
| Enrolling center type | <0.0001 | ||||
| Academic | 471 (44.8) | 799 (61.8) | 889 (78.7) | 2,159 (62.1) | |
| Community | 581 (55.2) | 494 (38.2) | 240 (21.3) | 1,315 (37.9) | |
| Enrolling center specialty | 0.0472 | ||||
| Gastroenterology/hepatology | 1,024 (97.3) | 1,274 (98.5) | 1,113 (98.6) | 3,411 (98.2) | |
| Endocrinology | 28 (2.7) | 19 (1.5) | 16 (1.4) | 63 (1.8) | |
*
Severity of liver disease at the time of enrollment.
†
BMI calculated based on the most recent height and weight measurement up to or at the time of enrollment. Some cells may not add to 100, as very small proportions were excluded for readability.
‡
Inclusive of magnetic resonance imaging, computed tomography, or ultrasound.