TABLE 1.
Baseline characteristics and clinical data for patients with native liver disease and liver transplant recipients infected with severe acute respiratory syndrome coronavirus-2
| Native liver disease, N = 44 | Liver transplant recipient, N = 47 | |
| Baseline characteristics | ||
| Age, years; median (IQR) | 11 (0.9–17) | 10 (4–16) |
| Male gender, % | 26 (59) | 22 (46.8) |
| Race and ethnicity, % | ||
| White | 20 (45.5) | 20 (42.6) |
| Hispanic | 13 (29.5) | 18 (38.2) |
| Black | 5 (11.4) | 2 (4.3) |
| Asian | 4 (9.1) | 3 (6.4) |
| Other | 2 (4.5) | 3 (6.4) |
| Missing | 0 | 1 (2.1) |
| Primary liver condition, % | ||
| Biliary atresia | 10 (22.7) | 20 (42.6) |
| Autoimmune hepatitis | 8 (18.2) | 3 (6.4) |
| Acute liver failure | 4 (9.2) | 7 (14.9) |
| NAFLD | 10 (22.7) | 0 |
| Metabolic∗ | 3 (6.8) | 6 (12.8) |
| Malignancy | 2 (4.5) | 5 (10.6) |
| Other cholestatic liver disease | 5 (11.4) | 1 (2.1) |
| Other† | 2 (4.5) | 5 (10.6) |
| Comorbid conditions, %‡ | ||
| None | 15 (34) | 28 (59.6) |
| Obesity | 14 (31.8) | 3 (6.4) |
| Cardiac | 6 (13.6) | 5 (10.6) |
| Pulmonary | 5 (11.4) | 3 (6.4) |
| Gastrointestinal | 5 (11.4) | 1 (2.1) |
| Endocrine | 2 (4.5) | 2 (4.3) |
| Renal | 1 (2.3) | 3 (6.4) |
| Other autoimmune conditions | 1 (2.3) | 3 (6.4) |
| Clinical data | ||
| Presenting symptoms, %‡ | ||
| Respiratory symptoms | 22 (50) | 17 (36.2) |
| Fever | 21 (47.8) | 16 (34) |
| Gastrointestinal symptoms | 12 (27.3) | 12 (25.5) |
| Constitutional symptoms§ | 4 (9.1) | 3 (6.4) |
| Asymptomatic | 8 (18.2) | 13 (27.7) |
| Method of SARS-CoV2 diagnosis, % | ||
| NP swab | 35 (79.5) | 39 (83) |
| Serum antibody | 6 (13.6) | 8 (17) |
| NP swab + serum antibody | 3 (6.9) | 0 |
| Imaging findings‡ | ||
| CXR: normal | 11 (25) | 8 (10.6) |
| CXR: diffuse patchy opacities | 9 (20.5) | 2 (4.3) |
| CXR: interstitial pneumonia | 2 (4.5) | 2 (2.1) |
| CXR: lobar pneumonia | 2 (4.5) | 0 |
| Chest CT: ground-glass opacities | 1 (2.3) | 0 |
| Imaging data not available | 20 (45.5) | 35 (74.4) |
| Liver biopsy performed | 1 (2.3) | 3 (6.4) |
CT = computed tomography; CXR = chest X-ray; IQR = interquartile range; n = number; NAFLD = nonalcoholic fatty liver disease; NP = nasopharyngeal; SARS-CoV2 = severe acute respiratory syndrome coronavirus-2.
Cystic fibrosis, alpha-1 antitrypsin deficiency, citrullinemia; liver transplant: ornithine transcarbamylase deficiency, maple syrup urine disease, urea cycle disorder, glycogen storage disease.
GVHD with cirrhosis, idiopathic portal vein thrombosis; liver transplant: cryptogenic (n = 2), factor V deficiency, Ellis Van Creveld syndrome, hereditary hemochromatosis.
Category is not mutually exclusive.
Fatigue, sore throat, myalgia, loss of smell or taste.