Figure 2:

Longitudinal response categorization. At each imaging time point, the patient will receive a single categorical response. When there is a partial treatment response (PR), the time point with the smallest tumor burden is the nadir (green arrow). Provided there are no changes in nontarget lesions and no new lesions, when the smallest tumor burden increases by more than 20% from nadir (or baseline [yellow arrow], if no nadir), this is the date of disease progression (PD) (red arrow). Lines on bottom images indicate tumor diameter.