Table 2.
Accuracy of indirect fibrosis markers in detecting advanced fibrosis in a cohort of 231 patients referred from primary care with suspected alcohol-related liver disease (N=225/231)
| Indirect fibrosis test (N=225/231) | Correctly classifies | Sensitivity (95% CI) |
Specificity (95% CI) |
PPV (95% CI) |
NPV (95% CI) |
LR+ (95% CI) |
LR- (95% CI) |
TP FP |
FN TN |
False negative rate (%) | False positive rate (%) |
| APRI ≥1 |
165 (73.3%) |
64.6% (54% to 75%) |
78.3% (70% to 85%) |
63.1% (52% to 73%) |
80% (72% to 86%) |
3.02 (2.13 to 4.28) |
0.44 (0.33 to 0.6) |
53 | 29 | 35.4 | 21.7 |
| 31 | 112 | ||||||||||
| FIB4 ≥3.25 |
170 (75.6%) |
52.4% (41.2% to 63.5%) |
88.8% (82.2% to 93.3%) |
72.9% (59.5% to 83.3%) |
76.5% (69.1% to 82.6%) |
4.69 (2.83 to 7.77) |
0.54 (0.43 to 0.67) |
43 | 39 | 47.6 | 11.2 |
| 16 | 127 | ||||||||||
| FIB4 ≥1.45 | 149 (66%) | 78% (67.3% to 86.1%) |
59.4% (50.9% to 67.4%) |
52.4% (43.3% to 61.5%) |
82.5% (73.5% to 89%) |
1.92 (1.53 to 2.42) |
0.37 (0.24 to 0.56) |
64 | 18 | 22 | 40.6 |
| 58 | 85 |
APRI, AST to Platelet Ratio Index; FIB4, fibrosis 4 score; LR, likelihood ratio; NPV, negative predictive value; PPV, positive predictive value.