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. 2021 May 24;11:664848. doi: 10.3389/fonc.2021.664848

Figure 1.

Figure 1

THZ1 inhibits cell proliferation in breast cancer cells. (A) Cell Counting Kit-8 assays have determined the proliferation of breast cancer cells after treatment with dimethyl sulfoxide (DMSO) (control) or indicated concentrations of THZ1 (12.5, 25, 50, 100, 200, and 400 nM) for 48 h. (B) Images (200×) show Hs-578T, DU4475, and MCF-7 cells following THZ1 treatment for 48 h. (C) Effects of THZ1 treatment on breast cancer cell proliferation curve. Verification was performed by cell counting. (D) Impact of treatment with THZ1 on the development of breast cancer cells in the colony. Cells have been treated with either DMSO (control) or indicated THZ1 concentrations (12.5, 25, and 50 nM) for 7 days. With an inverted microscope, cell colonies (>50 cells) were counted. The mean ± standard deviation reflects the data. (n.s., non significant, P > 0.05; ***P < 0.001, ****P < 0.0001, n = 3).