Table 4: Optimal parameters for the addition phase of CPA equilibration for all three tissue types and associated time and toxicity costs.
Ctox, Ctime, and Cstd, represent protocols for the minimizer of the toxicity cost, the minimizer of the time cost, and the standard equilibration approach to the goal concentration. Concentrations are given in mol/L, and times in seconds and boldfaced concentrations are at the defined concentration limit. The parameter tf is the total protocol time at which the minimal concentration in the tissue is predicted to be 4.5 mol/L, our arbitrary cutoff. For the standard protocols with only three steps, the defined third step of 25 min is replaced with a step of duration long enough that the tf condition was met. Finally, note that these protocols are for the geometries and diffusivities used in the model explicitly and will not generalize to larger or smaller tissues.
| CPA Addition Parameters | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| C1 | C2 | C3 | C4 | t1 | t2 | t3 | tf | Jtox | |
| Ctox | 1.6 | 3.1 | 7.4 | 4.6 | 323 | 226 | 502 | 3712 | 1152 |
| Ctime | 3.4 | 5.1 | 7.5 | 12 | 4 | 4 | 5 | 1692 | 1666 |
| Cstd | 1.5 | 3.0 | 6.0 | --- | 600 | 1500 | --- | 4456 | 1304 |
| Fibroid | |||||||||
| Ctox | 3.7 | 6.4 | 9.0 | 4.5 | 169 | 83 | 125 | 1502 | 574 |
| Ctime | 3.6 | 4.9 | 7.5 | 12 | 4 | 4 | 5 | 856 | 833 |
| Cstd | 1.5 | 3.0 | 6.0 | --- | 600 | 1500 | --- | 3094 | 762 |
| Myometrium | |||||||||
| Ctox | 2.1 | 4.6 | 9.3 | 4.5 | 144 | 92 | 139 | 1486 | 526 |
| Ctime | 3.6 | 4.9 | 7.5 | 12 | 4 | 4 | 5 | 792 | 769 |
| Cstd | 1.5 | 3.0 | 6.0 | --- | 600 | 1500 | --- | 3000 | 726 |