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. 2021 May 24;12:673912. doi: 10.3389/fimmu.2021.673912

Figure 4.

Figure 4

PD-L1 induction on monocytes correlates with disease markers and activity. (A–C) Correlation of IFNγ-induced PD-L1 expression with ANCA titers, serum levels of CRP, and blood monocyte counts in patients with AAV (n=26). IFNγ-induced PD-L1 expression on monocytes compared between AAV patients with (D) either active or inactive disease (active n=8, inactive n=18) and (E) with or without renal AAV (renal AAV n=17, without renal AAV n=9). Spearman correlation (A–C) and unpaired t-test (D, E) were applied. *P<0.05; **P<0.01. Bar graph shows mean ± SEM. AAV, ANCA-associated vasculitis; HC, healthy control donors; MFI, mean fluorescence intensity; PD-L1, Programmed death-ligand 1; ANCA, Anti-neutrophil cytoplasmic antibodies; CRP, C-reactive protein; ns, statistically not significant.