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. 2021 May 24;12:673912. doi: 10.3389/fimmu.2021.673912

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Copyright © 2021 Zeisbrich, Chevalier, Sehnert, Rizzi, Venhoff, Thiel and Voll

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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PD-L1/CMTM6-defect is passed to monocyte-derived macrophages. (A) Representative histograms of PD-L1 expression (MFI) on monocyte-derived macrophages after differentiation with M-CSF or GM-CSF for 6 days. (B) Summarizing scatter dot plot presenting results from experiments with cells from HC or AAV patients (n=7 each group). (C) Expression of CMTM6 protein in monocyte-derived macrophages from HC or AAV patients (n=7 each group). Mann-Whitney test (B, C) was applied. **P<0.01; ***P<0.001. Bar graph shows mean ± SEM. Bar graph shows mean ± SEM. AAV, ANCA-associated vasculitis; HC, healthy control donors; MFI, mean fluorescence intensity; PD-L1, Programmed death-ligand 1; M-CSF, macrophage colony-stimulating factor; GM-CSF, Granulocyte-macrophage colony-stimulating factor; ns, statistically not significant.