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Penetration of nanoparticles into H1975 tumor spheroids. (A) Fluorescence distribution across different depths after being treated with free CY3-siRNA (a), PEI/CY3-siRNA (b), HA-PEI)/CY3-siRNA (c), HA-P-PEI/CY3-siRNA (d), and HA-P-PEI/CY3-siRNA (MMP-2 pretreatment) (e). Magnification: 200×. (B) Semi-quantitative intensity across different sections of H1975 tumor spheroids.
