Table 3.
The hub genes miRNA expressed in normal adipose tissue using BioGPS and related disease by CTD
| Groups | Hub genes | Adipose tissue | Adipose tissue omental | Related Disease | Inference Score |
|---|---|---|---|---|---|
| BMI > 35 kg/m2:DM VS NDM | TRDN | 0.37 ± 0.19 | 0.48 ± 0.09 | Weight Loss | 37.25 |
| PLN | 10.13 ± 2.16 | 6.33 ± 1.16 | Glucose Intolerance | 37.13 | |
| MYH11 | 9.08 ± 1.83 | 9.36 ± 0.60 | Weight Loss | 100.69 | |
| BMI 18–24.9 kg/m2:DM VS NDM | COL4A2 | 17.04 ± 0.69 | 16.53 ± 0.27 | Weight Loss | 92.25 |
| COL6A6 | 5.80 ± 2.80 | 5.21 ± 1.05 | Diabetes Mellitus | 16.00 | |
| ACACB | 6.25 ± 1.61 | 9.03 ± 0.19 | Insulin Resistance | 85.45 | |
| GLUL | 11.26 ± 0.94 | 11.23 ± 0.77 | Weight Loss | 175.47 | |
| ELOVL7 | 9.41 ± 1.43 | 1.19 ± 0.37 | Weight Loss | 77.78 | |
| MYH2 | −0.76 ± 3.09 | −0.23 ± 1.19 | Insulin Resistance | 40.55 | |
| DM: BMI>35 kg/m2 VS 18–24.9 kg/m2 | CD36 | 19.01 ± 0.75 | 16.29 ± 0.41 | Weight Loss | 239.26 |
| FCGR2A | 4.96 ± 1.16 | 2.48 ± 1.00 | Weight Loss | 34.41 | |
| PTPRC | 5.57 ± 1.42 | 2.78 ± 0.35 | Weight Loss | 84.92 | |
| CD163 | 0.86 ± 0.59 | 0.7 ± 0.12 | Weight Loss | 98.07 | |
| MS4A6A | 7.76 ± 1.17 | 7.56 ± 1.00 | Glucose Intolerance | 33.85 | |
| DM: BMI 24.9–35 kg/m2 VS 18–24.9 kg/m2 | TNNC2 | 1.14 ± 0.37 | 0.42 ± 0.17 | Weight Loss | 70.86 |
| MYH2 | −0.76 ± 3.09 | −0.23 ± 1.19 | Insulin Resistance | 40.55 |
CTD: comparative toxicogenomics database; BMI: Body mass index; DM: type 2 diabetes; NDM: non-diabetes. mean± SD: miRNA expression