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. 2021 Jun 4;22(1):404–428. doi: 10.1080/14686996.2021.1924044

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© 2021 The Author(s). Published by National Institute for Materials Science in partnership with Taylor & Francis Group.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Figure 2. — (a) Schematic representation of stimuli-responsive DOX-loaded AuNC/HA nanoparticles for pinpointed intracellular drug release and synergistic therapy. (b) The DOX release profiles from DOX/AuNCs/HA in acetate buffer at pH 4.5: (1) control, (2) upon NIR irradiation, (3) in the presence of hyaluronidase, (4) in the presence of Hyal upon NIR irradiation. (c) Live/dead and flow cytometry apoptosis assay. (d) The relative tumor volumes of nude mice versus time after treatment. Control (a), AuNCs/HA upon NIR irradiation (b), DOX/AuNCs/HA (c), DOX/AuNCs/HA upon NIR irradiation (d). Reproduced with permission [76]