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. Author manuscript; available in PMC: 2021 Aug 4.
Published in final edited form as: Nat Methods. 2021 Feb 4;18(2):176–185. doi: 10.1038/s41592-020-01049-4

Extended Data Figure 7. Validation of LSU class C4 with cryoSPARC.

Extended Data Figure 7.

A) Density map from cryoSPARC homogeneous refinement of the 1,113 particles selected from the cryoDRGN latent representation that constitute class C4 (right), compared with the density map generated by cryoDRGN (left) from Figure 5I. rRNA helix 68 is circled in red.

B) Gold standard FSC (GSFSC) curve between independent half-maps of the cryoSPARC reconstruction and map-to-map FSC between the cryoDRGN and cryoSPARC maps shown in (A). Dotted lines indicate 0.5 and 0.143 cutoffs.

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