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Nervonic acid-enrichment of a HFD leads to energy expenditure values similar to control mice. (A) VO2, (B) VCO2, (C) RER, (D) Heat, (E & F) locomotion were assessed by placing mice on indicated diets in metabolic cages. Shaded region in (E) represents the dark cycle (n = 10–12 mice/group **P < .01, ***P < .001). Two-way ANOVA demonstrates a significant interaction of diet with NA for VO2, VCO2, and heat in the light cycle (P < .05)
