Table 2. Study design and primary endpoints of clinical trials involving gastrectomy for GC as found on ClinicalTrials.gov as of 1 May 2020.
| NA | Phase I | Phase I/II | Phase II | Phase II/III | Phase III | Phase IV | Total (%) | |
|---|---|---|---|---|---|---|---|---|
| Interventional mode | ||||||||
| Single group assignment | 10 | - | 2 | 12 | - | 1 | - | 25 (18%) |
| Parallel assignment | 52 | 2 | 1 | 14 | 3 | 40 | 1 | 113 (82%) |
| Treatment allocation | ||||||||
| Nonrandomised | 6 | - | - | - | 1 | 1 | - | 8 (6%) |
| Randomised | 49 | 2 | 1 | 14 | 2 | 39 | 1 | 108 (78%) |
| Not specified | 7 | - | 2 | 12 | - | 1 | - | 22 (16%) |
| Masking | ||||||||
| Open label (none) | 42 | - | 2 | 24 | 3 | 36 | - | 107 (78%) |
| Masked | 20 | 2 | - | 2 | - | 5 | 1 | 30 (22%) |
| Not specified | - | - | 1 | - | - | - | - | 1 (1%) |
| Main primary endpoint | ||||||||
| 30-day reoperation | 1 | - | - | - | - | - | - | 1 (1%) |
| Number of harvested lymph nodes | 5 | - | 1 | 5 | - | 3 | - | 14 (10%) |
| Operation time | 4 | - | - | 1 | - | 1 | - | 6 (4%) |
| Overall survival | 4 | - | - | 4 | 2 | 15 | - | 25 (18%) |
| Percentage body weight ratio | - | - | - | - | - | 1 | - | 1 (1%) |
| Postoperative length of stay | 3 | - | - | 1 | - | 1 | - | 5 (4%) |
| Postoperative morbidity | 6 | - | 1 | 2 | - | 2 | - | 11 (8%) |
| Postoperative outcomes | 16 | - | - | 5 | - | 3 | 1 | 25 (18%) |
| Progression-free survival | 17 | 1 | - | 7 | 1 | 12 | - | 38 (28%) |
| Quality of life | 3 | 1 | - | 1 | - | 3 | - | 8 (6%) |
| Rate of conversion | - | - | 1 | - | - | - | - | 1 (1%) |
| Time to drain removal | 1 | - | - | - | - | - | - | 1 (1%) |
| Tumour recurrence rate | 2 | - | - | - | - | - | - | 2 (1%) |