Table 2.
Prediction of miRNAs binding to circ_0049447 and their validated functions in cancer.
| Potential miRNAs | Target genes | Function | Tumor types | Reference |
| miR-1204 | ZNF418 | Promote proliferation, inhibit apoptosis | Hepatocellular carcinoma | [19] |
| NR3C2 | Aggravate proliferation, suppress apoptosis | Glioblastoma | [20] | |
| PITX1 | Promote proliferation | Non-small cell lung cancer | [21] | |
| VDR | Promote proliferation, invasion, and EMT | Breast cancer | [22] | |
| miR-324-5p | FBXO11 | Chemotherapy resistance | Non-small cell lung cancer | [23] |
| PTPRD | Promote migration and invasion | Papillary thyroid carcinoma | [24] | |
| miR-661 | RB1 | Promote proliferation and metastasis | Non-small cell lung cancer | [25] |
| RUNX3 | Promote proliferation and invasion | [26] | ||
| INPP5J | Promote proliferation | Ovarian cancer | [27] | |
| Nectin-1, StarD10 | Promote invasion | Breast cancer | [28] | |
| miR-663b | APC2 | Promote proliferation, migration, and invasion | Colorectal cancer | [29] |
| TNK1 | Promote proliferation and stemness | [30] | ||
| ERF | Promote proliferation and EMT | Bladder cancer | [31] | |
| SMAD7 | Promote proliferation and EMT | Nasopharyngeal carcinoma | [32] | |
| TP73 | Promote proliferation, inhibit apoptosis | Osteosarcoma | [33] | |
| miR-671-5p | TRIM67 | Promote proliferation, migration, and invasion | Colon cancer | [34] |
| APC | Promoted migration and invasion | Clear cell renal cell carcinoma | [35] | |
| CDR1 | Promote proliferation, migration, and invasion | Glioblastoma | [36] | |
| miR-431 | DAB2IP | Promote migration and invasion | Pancreatic neuroendocrine cancer | [37] |
APC: Adenomatous polyposis coli; APC2: Adenomatous polyposis coli 2; CDR1: Cerebellar degeneration-related protein 1; DAB2IP: DAB2-interacting protein; EMT: Epithelial-mesenchymal transition; ERF: Ets2-repressor factor; FBXO11: F-box protein 11; INPP5J: Inositol polyphosphate-5-phosphatase J; miRNAs: MicroRNAs; NR3C2: Nuclear receptor subfamily 3 group C member 2; PITX1: Paired like homeodomain 1; PTPRD: Protein tyrosine phosphatase receptor delta; RB1: RB transcriptional corepressor 1; RUNX3: Runt-related transcription factor 3; SMAD7: SMAD family member 7; TNK1: Tyrosine kinase non-receptor 1; TP73: Tumor protein p73; TRIM67: Tripartite motif-containing 67; VDR: Vitamin D receptor; ZNF418: Zinc-finger protein 418.