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Effect of long-term premature ventricular contractions (PVCs) on left ventricular ejection fraction (LVEF) and geometry. Progression of (A) LVEF, (B) LV end-diastolic (LVEDV) and (C) end-systolic volumes (LVESV), (D) LV mass index, and (E) relative wall thickness (RWT) after a long-term exposure to bigeminal PVCs (n = 4, 48-week follow-up). Solid lines represent each individual animal. Red dashed line represents mean value. (‡) P < .05 vs baseline.
