Table 2.
Patients with MLC classified by the Martini and Melamed criteria and molecular methods.
| Case No. | Martini & Melamed criteria | Mutational evaluation | Number of matching mutations | Matching genes |
|---|---|---|---|---|
| Martini and Melamed criteria-based MPLC cases (n = 18) | ||||
| 1 | MPLC | MPLC | 0 | – |
| 2 | MPLC | MPLC | 0 | – |
| 3 | MPLC | MPLC | 0 | – |
| 6 | MPLC | MPLC | 0 | – |
| 7 | MPLC | MPLC | 0 | – |
| 10 | MPLC | MPLC | 0 | – |
| 12 | MPLC | MPLC | 1 | TERT Amplification |
| 13 | MPLC | MPLC | 0 | – |
| 15 | MPLC | MPLC | 0 | – |
| 20 | MPLC | MPLC | 1 | EGFR L858R |
| 21 | MPLC | MPLC | 0 | – |
| 24 | MPLC | MPLC | 0 | – |
| 25 | MPLC | MPLC | 0 | – |
| 26 | MPLC | MPLC | 0 | – |
| 27 | MPLC | MPLC | 0 | – |
| 9 | MPLC | IM | 4 | EGFR/ALK/TP53/IKZF2 |
| 29 a | MPLC | IM | 1 | EGFR L858R/T790M |
| 30 | MPLC | IM | 1 | EGFR 19Del |
| Martini & Melamed criteria-based IM cases (n = 12) | ||||
| 4 | IM | MPLC | 0 | – |
| 5 | IM | MPLC | 0 | – |
| 11 | IM | MPLC | 0 | – |
| 14 a | IM | MPLC | 0 | – |
| 16 | IM | MPLC | 1 | EGFR L858R |
| 17 a | IM | MPLC | 1 | EGFR L858R |
| 18 | IM | MPLC | 0 | – |
| 19 | IM | MPLC | 0 | – |
| 22 | IM | MPLC | 0 | – |
| 23 | IM | MPLC | 1 | EGFR L858R |
| 28 | IM | MPLC | 0 | – |
| 8 | IM | IM | 10 | EGFR/KDM6A/KMT2D |
a
Tumor 1 vs Tumor 2.
IM, intrapulmonary metastasis; MPLC, multiple primary lung cancer.