TABLE 2.

Clinical features of family members carrying the NM_001256443:c.641dupC mutation

Feature	Patient
	a	b	c
Age, years	54	60	56
Age at onset	44	20	46
Spastic gait	+	Wheelchair from last 5 years	+
Urinary urgency	−	−	−
Scoliosis	−	+	−
Upper limbs
Weakness	−	−	−
Sensory loss	−	−	−
Lower limbs
Increased tone	+	+	+
Hyperreflexia	+	+	+
Weakness	+	+	+
Extensor plantar response	+	+	+
Sensory loss	+	+	+
Decreased vibration sense	+	+	+

(+), present; (−), absent.