Table 1.
Patient characteristics
| Demographics | Channelopathy (N = 199) |
No channelopathy (N = 786) |
P value | ||
|---|---|---|---|---|---|
| n | Value† | n | Value† | ||
| Age (y) | 199 | 39 ± 14 | 786 | 51 ± 17 | <.001 |
| Male | 125 (62.8) | 584 | 74.3 | <.01 | |
| Height (cm) | 176 | 174 ± 11 | 692 | 175 ± 10 | ns |
| Weight (kg) | 179 | 79 ± 19 | 691 | 84 ± 20 | <.01 |
| BMI (kg/m2) | 176 | 26 ± 5 | 675 | 27 ± 6 | <.01 |
| LVEF (%) | 122 | 59 ± 9 | 666 | 41 ± 18 | <.001 |
| QRS duration (ms) | 188 | 99 ± 19 | 717 | 108 ± 26 | <.001 |
| Primary prevention | 115 (57.8) | 523 (66.5) | <.05 | ||
| Medical history | |||||
| Hypertension | 18 (9.0) | 261 (33.2) | <.001 | ||
| Myocardial infarction | 9 (4.5) | 268 (34.1) | <.001 | ||
| Cardiac arrest | 69 (34.7) | 206 (26.2) | <.05 | ||
| Congestive heart failure | 5 (2.5) | 256 (32.6) | <.001 | ||
| Syncope | 71 (35.7) | 115 (14.6) | <.001 | ||
| Atrial fibrillation | 8 (4.0) | 149 (19.0) | <.001 | ||
| Valve disease | 4 (2.0) | 116 (14.8) | <.001 | ||
| Diabetes | 7 (3.5) | 104 (13.2) | <.001 | ||
| Kidney disease | 3 (1.5) | 78 (9.9) | <.001 | ||
| Stroke (including TIA) | 3 (1.5) | 48 (6.1) | <.01 | ||
| COPD | 3 (1.5) | 46 (5.9) | <.05 | ||
| Previous TV-ICD | 22 (11.1) | 116 (14.8) | ns | ||
| CABG | 2 (1.0) | 76 (9.7) | <.001 | ||
| Valve surgery | 1 (0.5) | 61 (7.8) | <.001 | ||
| Pacemaker implant | 1 (0.5) | 29 (3.7) | <.05 | ||
| Primary cardiac disease | |||||
| Channelopathy | 199 (100.0) | 0 | <.001 | ||
| Brugada | 83 (41.7) | ||||
| CPVT | 11 (5.5) | ||||
| IVF | 78 (39.2) | ||||
| Long QT syndrome | 24 (12.1) | ||||
| Short QT syndrome | 3 (1.5) | ||||
| Ischemic cardiomyopathy‡ | 0 | 282 (35.9) | <.001 | ||
| Nonischemic cardiomyopathy§ | 0 | 313 (39.8) | <.001 | ||
| Other‖ | 0 | 115 (14.6) | <.001 | ||
| Unknown | 0 | 76 (9.7) | <.001 | ||
BMI = body mass index; CABG = coronary artery bypass graft; COPD = chronic obstructive pulmonary disease; CPVT = catecholaminergic polymorphic ventricular tachycardia; IVF = idiopathic ventricular fibrillation; LVEF = left ventricular ejection fraction; ns = nonsignificant; std = standard deviation; TIA = transient ischemic attack; TV-ICD = transvenous implantable cardioverter-defibrillator.
Values are number (%) of patients or mean ± standard deviation unless otherwise indicated.
Coronary artery disease, ischemic, previous myocardial infarction
Arrhythmogenic right ventricular dysplasia, dilated cardiomyopathy, hypertrophic cardiomyopathy.
Includes structural defect, genetic, syncope of unknown origin, congestive heart failure, ventricular arrhythmia, myocarditis, cardiac sarcoidosis.