Table 4.
Primary and secondary outcomes in patients without atrial fibrillation
| Overall |
|||
|---|---|---|---|
| No ablation | Ablation | P value | |
| HFrEF | |||
| Patients (n) | 3271 | 801 | |
| Primary outcome at 1 year (%)† | 14.7 | 10.0 | .001 |
| Primary outcome at 1 year (HR, 95% CI)‡ | 0.66 (0.52–0.84) | .001 | |
| HF readmission at 1 year (%)† | 11.0 | 7.7 | .006 |
| HF readmission at 1 year (HR, 95% CI)‡ | 0.69 (0.52–0.90) | .006 | |
| Mortality at 1 year (%)† | 4.9 | 2.4 | .002 |
| Mortality at 1 year (HR, 95% CI) (univariate)‡ | 0.48 (0.30–0.77) | .002 | |
| AF readmission at 1 year (%)† | 3.8 | 2.4 | .040 |
| AF readmission at 1 year (HR, 95% CI)‡ | 0.61 (0.37–0.98) | .042 | |
| Any readmission at 1 year (%)† | 34.8 | 25.8 | <.001 |
| Any readmission at 1 year (HR, 95% CI)‡ | 0.70 (0.60–0.80) | <.001 | |
| AFL readmission at 1 year (%)† | 6.8 | 1.5 | <.001 |
| AFL readmission at 1 year (HR, 95% CI)‡ | 0.21 (0.12–0.38) | <.001 | |
| HFpEF | |||
| Patients (n) | 1970 | 314 | |
| Primary outcome at 1 year (%)† | 12.9 | 11.5 | .488 |
| Primary outcome at 1 year (HR, 95% CI)‡ | 0.88 (0.62–1.25) | .489 | |
| HF readmission at 1 year (%)† | 9.5 | 10.2 | .713 |
| HF readmission at 1 year (HR, 95% CI)‡ | 1.07 (0.74–1.56) | .713 | |
| Mortality at 1 year (%)† | 4.2 | 2.2 | .088 |
| Mortality at 1 year (HR, 95% CI)‡ | 0.52 (0.24–1.12) | .094 | |
| AF readmission at 1 year (%)† | 5.0 | 3.8 | .334 |
| AF readmission at 1 year (HR, 95% CI)‡ | 0.75 (0.41–1.36) | .336 | |
| Any readmission at 1 year (%)† | 38.9 | 34.7 | .137 |
| Any readmission at 1 year (HR, 95% CI)‡ | 0.86 (0.70–1.05) | .138 | |
| AFL readmission at 1 year (%)† | 6.5 | 2.9 | .010 |
| AFL readmission at 1 year (HR, 95% CI)‡ | 0.42 (0.22–0.83) | .012 | |
AF = atrial fibrillation; AFL = atrial flutter; HF = heart failure; HFpEF = heart failure with preserved ejection fraction; HFrEF = heart failure with reduced ejection fraction.
†
Log-rank test.
‡
Cox proportional regression models: Individual models were run for respective outcome.