Table 2. Gene products identified as likely targets of allele-specific immunity to malaria based on two analytical approaches.

Gene ID	Annotation	GO Function	GO Process
PF3D7_0311900	heptatricopeptide repeat-containing protein, putative	null	null
PF3D7_0312500	major facilitator superfamily-related transporter, putative	null	transmembrane transport
PF3D7_0318200	DNA-directed RNA polymerase II subunit RPB1	DNA-directed 5’-3’ RNA polymerase activity	transcription
PF3D7_0412300	phosphopantothenoylcysteine synthetase, putative	null	null
PF3D7_0421700	conserved Plasmodium protein, unknown function	null	null
PF3D7_0424400	surface-associated interspersed protein 4.2 (SURFIN 4.2)	host cell surface binding	entry into host cell
PF3D7_0511500	RNA pseudouridylate synthase, putative	RNA binding, pseudouridine synthase activity	RNA modification, pseudouridine synthesis
PF3D7_0522400	conserved Plasmodium protein, unknown function	null	protein localization/transport
PF3D7_0526600	conserved Plasmodium protein, unknown function	null	lipid biosynthetic process
PF3D7_0605600	nucleoside diphosphate kinase, putative	nucleoside diphosphate kinase activity	nucleoside diphosphate phosphorylation
PF3D7_0619600	conserved Plasmodium protein, unknown function	null	null
PF3D7_0704600	E3 ubiquitin-protein ligase	ubiquitin-protein transferase activity	response to drug
PF3D7_0710200	conserved Plasmodium protein, unknown function	null	null
PF3D7_0807700	serine protease DegP	serine-type endopeptidase activity	response to oxidative stress and temperature stimulus
PF3D7_0831600	cytoadherence linked asexual protein 8	null	null
PF3D7_0914300	met-10+ like protein, putative	null	null
PF3D7_1004200	WD repeat-containing protein, putative	protein binding	transport
PF3D7_1030400	conserved protein, unknown function	null	null
PF3D7_1033100	S-adenosylmethionine/0rnithine decarboxylase	adenosylmethionine decarboxylase activity	spermidine/spermine biosynthetic processes
PF3D7_1035100	probable protein, unknown function	ATP binding	null
PF3D7_1102500	Plasmodium exported protein (PHISTb), unknown function	null	null
PF3D7_1149600	DnaJ protein, putative	null	null
PF3D7_1219100	clathrin heavy chain, putative	clathrin light chain binding, structural molecule activity	clathrin coat assembly, intracellular protein transport, vesicle-mediated transport
PF3D7_1465800	dynein beta chain, putative	ATP binding, microtubule motor activity	microtubule-based movement
PF3D7_1475900	KELT protein	null	null