Table I.
An overview of 122 COVID-19 trials registered in the Clinical Trials Registry - India#
| Intervention | Number | Type of trial | Participant health condition |
|---|---|---|---|
| Modern medicine (n=42) | |||
| Drug (n=28) | |||
| Individual drugs | 24 | Therapeutic efficacy=19 Prophylactic efficacy=5 |
Healthy volunteers at high risk - 4 Healthy volunteers at moderate/high risk - 1 Mild COVID-19 - 5 Mild-to-moderate COVID-19 - 1 Moderate COVID-19 - 1 Moderate-to-severe COVID-19 - 2 Severe COVID-19 - 4 Severity not specified - 6 |
| Combination drugs | 4 | Therapeutic efficacy=4 | Moderate COVID-19 - 1 Mild, moderate, severe COVID-19 - 1 Non-severe and severe COVID-19 - 1 Severity not specified - 1 |
| Phytopharmaceutical (n=2) | |||
| Phytopharmaceutical | 2 | Therapeutic efficacy=2 | Asymptomatic/mild COVID-19 - 1 Moderate COVID-19 - 1 |
| Cell- and plasma-based therapies (n=9) | |||
| Cell- and plasma-based therapies | 9 | Therapeutic efficacy=9 | Moderate COVID-19 - 1 Moderate-to-severe COVID-19 - 1 Severe COVID-19 - 5 Severity not specified - 2 |
| Biological products (n=3) | |||
| Vaccine | 3 | Therapeutic efficacy=2 Prophylactic efficacy=1 |
Healthy volunteers at high risk - 1 Moderate-to-severe COVID-19 - 1 Severe COVID-19 - 1 |
| Traditional medicine (n=67) Ayurveda (n=45) | |||
| Classical individual agents | 11 | Therapeutic efficacy=1 Prophylactic efficacy=10 |
Healthy volunteers at high risk - 1 Healthy volunteers in the community - 9 Asymptomatic/mild symptoms - 1 |
| Classical combination preparations* | 10 | Therapeutic efficacy=4 Prophylactic efficacy=6 |
Healthy volunteers at high risk - 1 Healthy volunteers in the community - 5 Asymptomatic/mild symptoms - 3 Mild-to-moderate COVID-19 - 1 |
| Patented products | 24 | Therapeutic efficacy=18 Prophylactic efficacy=6 |
Healthy volunteers at high risk - 5 Healthy volunteers in the community - 1 Asymptomatic/mild symptoms - 3 Asymptomatic/mild/moderate symptoms - 2 Mild symptoms - 4 Mild-to-moderate COVID-19 - 6 Moderate COVID-19 - 1 Moderate-to-severe COVID-19 - 1 Severe COVID-19 -1 |
| Yoga (n=3) | |||
| Yoga* | 3 | Therapeutic efficacy=2 Stress management=1 |
Healthy volunteers at high risk - 1 Asymptomatic/mild symptoms - 1 Asymptomatic/uncomplicated illness/mild pneumonia - 1 |
| Unani (n=2) | |||
| Unani | 2 | Prophylactic efficacy=2 | Healthy volunteers at risk - 2 |
| Siddha (n=3) | |||
| Siddha | 3 | Therapeutic efficacy=2 Prophylactic efficacy=1 |
Healthy volunteers in community and healthcare workers - 1 Asymptomatic - 1 Asymptomatic/mild/moderate symptoms - 1 |
| Homeopathy (n=14) | |||
| Homeopathy | 14 | Therapeutic efficacy=8 Prophylactic efficacy=6 |
Healthy volunteers in community - 3 Healthy volunteers at high risk - 3 Asymptomatic - 1 Asymptomatic/mild symptoms - 1 Mild - 4 Moderate - 1 Mild/moderate/severe symptoms - 1 |
| Miscellaneous (n=13) | |||
| Miscellaneous | 13 | Therapeutic efficacy=2 Prophylactic efficacy=1 Process-of-care changes=9 Diagnostic=1 |
Healthy volunteers - 4 Severe COVID-19 - 1 Severity not specified - 4 Other (non-COVID-19) - 4 |
#Registered trials as on June 5, 2020; *Two Ayurveda classical combination trials included yoga and one yoga trial included Ayurveda interventions. In addition, one Ayurveda trial was in combination with homeopathy and one miscellaneous trial with combination of modern medicine, Ayurveda and homeopathy