Fig 7. EI balance affects tuning curve shapes.

As NMDA receptor conductance of the pyramidal cells and interneurons were systematically manipulated, it resulted in the representational tuning curves changing in width. As the NMDA conductance manipulation approached the epileptic corner of network firing (top left in Fig 3), the tuning curves became wider, and as the networks became unable to initiate or maintain a representation (bottom right in Fig 3), the tuning curves became more narrow. Notably, as the NMDA conductance parameters were globally changed (moving along the bottom left to top right diagonal in Fig 3), there was no change in the tuning curve’s shape.