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. 2021 Jan 19;23(6):958–969. doi: 10.1093/europace/euaa369

Figure 5.

Figure 5

Continuous and stratified effects of age on left atrial action potential duration (LA-APD), atrial effective refractory period (ERP), and interatrial activation time (IA-AT). Graphs in the left column show atrial ERP (A1), LA-APD70 (B1), and IA-AT (C1), each at 100 ms pacing cycle length (PCL), plotted over mouse age in weeks at the time of experiment and results of linear regression. Linear regression was not statistically significant for all three parameters. Mice were then stratified in age groups (A2, B2, C2) and atrial ERP was found to be affected by age group (A2; ANOVA P < 0.0001). Age group results are shown as boxplots with min-to-max-whiskers. In Bonferroni-corrected post hoc testing, atrial ERP at 100 ms PCL was increased in younger groups (<3 months and 3–6 months) compared to older groups (6–12 and 12–24 months). *P < 0.05, ***P < 0.001, ****P < 0.0001.