Table 1. Main characteristics of eligible studies.
| Author, year, country | Sealer/Sample ( n ) | Age (mean in years) | Teeth diagnosis | Type of teeth | Obturation technique | Rescue medication | Pain scale assessment | Interval (in hours) |
|---|---|---|---|---|---|---|---|---|
| Abbreviations: F, female; M, male; VAS, visual analogic scale. 1 The study performed a split-mouth RCT. 2 The study did not separate the average age per group. 3 Retreatment. 4 It was not presented at the dosage of the drug. + It is not possible to extract the numerical results. | ||||||||
| Fonseca et al, 2019. Brazil | AHPlus: 32 (18F 14M) Sealer Plus BC: 32 (20F 12M) |
AHPlus: 37.09 ± 13.10 Sealer Plus BC: 38.5 ± 14.18 |
Pulp necrosis | Anterior teeth | Single-cone technique filling | 600 mg ibuprofen | VAS | 24, 48, 72, 168 |
| Ates et al, 2019. Turkey | AHPlus: 78 (47F 31M) iRoot SP: 78 (42F 36M) |
AHplus: 30.69 ± 10.39 (Vital teeth) 36.33 ± 11.08 (Necrotic teeth) iRoot SP: 35.00 ± 12.55 (Vital teeth) 40.69 ± 11.87 (Necrotic teeth) |
Pulp necrosis and vital teeth | Posterior teeth | Carrier-based system (Herofill SoftCore) |
200 mg ibuprofen | VAS | 6, 12, 24, 72 |
| Graunaite et al, 2018. Lithuania | AHPlus: 61 (36F 25M) Total Fill BC: 61 (36F 25M) 1 |
49.5 ± 12.82 2 | Asymptomatic apical periodontitis 3 | Anterior or posterior teeth | Warm vertical condensation (Calamus) | Nonsteroid analgesics | VAS | 24, 48, 72, 168 |
| Aslan and Dönmez Özkan, 2020. Turkey. | AHPlus: 30 BC Sealer: 30 EndoSeal MTA: 30 |
AHPlus: 37.15 ± 11.93 BC Sealer: 32.46 ± 13.20 EndoSeal MTA: 39.57 ± 13.09 |
Asymptomatic irreversible pulpitis | Posterior inferior molars | Single-cone technique filling | ibuprofen 400 mg | VAS | 6, 12, 24, 48, 72, 96,120,144 |
| Seh et al, 2020 Singapore |
AHPlus: 83 (45F 38M) Total Fill BC: 80 (42F 38M) |
+ | Pulp necrosis and vital teeth | Anterior or posterior teeth | Warm vertical condensation (System B) | Ibuprofen 4 | Likert scale |
24, 72, 168 |