Table 3. Cox regression analysis of prior cancer history impact on patients with thymoma.
| Variables | Hazard ratio (95% CI) | P value |
|---|---|---|
| Age (years) | ||
| ≤65 | Reference | |
| >65 | 2.22 (1.65–3.00) | <0.001 |
| Gender | ||
| Male | Reference | |
| Female | 0.84 (0.71–0.99) | 0.034 |
| Race | ||
| White | Reference | |
| Black | 1.10 (0.85–1.39) | 0.493 |
| Other/unknown | 0.81 (0.61–1.09) | 0.165 |
| Marital status | ||
| Married | Reference | |
| Single | 1.20 (0.91–1.57) | 0.201 |
| Separated/divorced/widowed | 1.51 (1.24–1.83) | < 0.001 |
| Unknown | 0.92 (0.60–1.41) | 0.693 |
| Year of diagnosis | ||
| 1975–1988 | Reference | |
| 1989–2002 | 1.11 (0.82–1.50) | 0.505 |
| 2003–2017 | 0.75 (0.52–1.09) | 0.137 |
| Masaoka-Koga stage | ||
| I/IIA | Reference | |
| IIB | 1.44 (1.05–1.97) | 0.025 |
| III/IV | 2.23 (1.54–3.24) | <0.001 |
| Unknown | 1.37 (0.93–2.01) | 0.111 |
| WHO type | ||
| A | Reference | |
| AB | 0.68 (0.44–1.04) | 0.072 |
| B1 | 0.85 (0.56–1.30) | 0.457 |
| B2 | 1.03 (0.68–1.57) | 0.875 |
| B3 | 1.08 (0.74–1.59) | 0.693 |
| NOS | 0.97 (0.69–1.37) | 0.859 |
| Size (mm) | ||
| <73 | Reference | |
| ≥73 | 1.22 (1.04–1.45) | 0.017 |
| Treatment | ||
| Surg only | Reference | |
| Surg and Chemo/Radia | 1.07 (0.87–1.32) | 0.498 |
| Chemo/Radia | 2.97 (2.33–3.79) | <0.001 |
| No treatment | 2.42 (1.80–3.26) | <0.001 |
| Prior cancer history | ||
| No | Reference | |
| Yes | 1.39 (1.18–1.63) | 0.017 |
HR, hazard ratio; CI, confidence interval; WHO, World Health Organization; NOS, not otherwise specified; Surg, surgery; Chemo, chemotherapy; Radia, radiation.