Skip to main content
. 2021 May;9(10):913. doi: 10.21037/atm-20-5032

Table 2. Cox regression analysis of survival outcome.

Variable Overall survival Cancer-specific survival
UVA MVA UVA MVA
HR 95% CI P HR 95% CI P HR 95% CI P HR 95% CI P
Chemo
   Cis q3wk 1 Ref 1 Ref 1 Ref 1 Ref
   Cis q1wk 1.36 1.03–1.79 0.03 0.97 0.72–1.30 0.82 1.69 1.21–2.36 0.002 1.17 0.81–1.70 0.4
   Others 1.79 1.36–2.37 <0.001 1.04 0.75–1.42 0.83 2.03 1.44–2.87 <0.001 1.05 0.70–1.57 0.81
ICT
   No 1 Ref 1 Ref 1 Ref 1 Ref
   Yes 1.54 1.12–2.12 0.007 1.29 0.90–1.85 0.17 1.8 1.25–2.59 0.002 1.46 0.96–2.23 0.07
Gender
   Male 1 Ref 1 Ref
   Female 1.13 0.85–1.50 0.41 1.08 0.76–1.53 0.66
Age (yrs)
   <61 1 Ref 1 Ref 1 Ref 1 Ref
   ≥61 1.57 1.24–1.97 <0.001 1.56 1.22–1.99 <0.001 1.57 1.19–2.08 0.001 1.68 1.25–2.26 <0.001
Smoker
   Never 1 Ref 1 Ref 1 Ref 1 Ref
   Former 1.92 1.36–2.72 <0.001 1.51 1.04–2.18 0.03 1.91 1.25–2.91 0.003 1.31 0.84–2.06 0.23
   Current 2.53 1.75–3.67 <0.001 2.23 1.51–3.30 <0.001 2.49 1.59–3.90 <0.001 1.98 1.23–3.17 0.005
HPV
   Negative 1 Ref 1 Ref 1 Ref 1 Ref
   Positive 0.51 0.37–0.71 <0.001 0.92 0.65–1.30 0.63 0.58 0.39–0.86 0.006 1.2 0.79–1.82 0.39
   NA
Comorbidity (no.)
   0 1 Ref 1 Ref
   1 0.8 0.56–1.13 0.21 0.74 0.49–1.12 0.15
   2 1.1 0.78–1.55 0.59 0.94 0.63–1.41 0.78
   3+ 1.23 0.88–1.73 0.23 0.99 0.66–1.48 0.97
T stage
   X 2.43 0.34–17.43 0.38 3.75 0.52–27.16 0.19
   0–2 1 Ref 1 Ref 1 Ref 1 Ref
   3–4 2.32 1.81–2.97 <0.001 1.87 1.44–2.41 <0.001 2.95 2.15–4.05 <0.001 2.33 1.69–3.21 <0.001
N stage
   0–1 1 Ref 1 Ref
   2–3 0.95 0.74–1.22 0.69 1.14 0.84–1.55 0.41
   NA
M stage
   0 1 Ref 1 Ref 1 Ref 1 Ref
   1 3.89 2.17–6.95 <0.001 1.02 0.49–2.14 0.96 3.87 1.98–7.59 <0.001 0.77 0.35–1.70 0.52
   NA
Histology
   Squamous 1 Ref 1 Ref 1 Ref 1 Ref
   Other 2 1.31–3.06 0.001 0.87 0.46–1.63 0.66 2.3 1.42–3.74 <0.001 0.98 0.43–2.21 0.96
Primary site
   NA 1 Ref 1 Ref 1 Ref 1 Ref
   OC 0.84 0.54–1.31 0.44 0.93 0.56–1.54 0.77
   NP 0.68 0.32–1.44 0.32 0.77 0.34–1.73 0.53
   OP 0.43 0.30–0.61 <0.001 1.13 0.73–1.73 0.59 0.39 0.26–0.59 <0.001 1.08 0.63–1.83 0.78
   HP 0.95 0.59–1.54 0.84 0.89 0.50–1.58 0.68
   Glottis 0.8 0.52–1.22 0.3 0.68 0.41–1.15 0.15
   Salivary 0.78 0.35–1.73 0.54 0.96 0.40–2.27 0.92
   Other 0.33 0.08–1.34 0.12 0.46 0.11–1.91 0.29
   Unknown 0.39 0.22–0.69 0.001 1.07 0.54–2.12 0.84 0.29 0.13–0.61 0.001 0.86 0.35–2.12 0.75
   Multiple 1.15 0.70–1.87 0.59 0.93 0.51–1.70 0.81
RT total dose (Gy)
   <70 1 Ref 1 Ref 1 Ref 1 Ref
   ≥70 0.66 0.50–0.86 0.002 0.82 0.60–1.11 0.2 0.57 0.42–0.78 <0.001 0.72 0.51–1.03 0.07
RT start year
   <2011 1 Ref 1 Ref
   ≥2011 0.91 0.71–1.17 0.49 0.97 0.72–1.31 0.84
RT complete
   No 1 Ref 1 Ref 1 Ref 1 Ref
   Yes 0.16 0.10–0.25 <0.001 0.53 0.33–0.86 0.01 0.12 0.08–0.20 <0.001 0.44 0.27–0.71 0.001
Response
   None 1 Ref 1 Ref 1 Ref 1 Ref
   Partial 0.08 0.05–0.12 <0.001 0.08 0.05–0.13 <0.001 0.05 0.03–0.08 <0.001 0.05 0.03–0.08 <0.001
   Complete 0.5 0.31–0.81 0.005 0.45 0.27–0.75 0.002 0.46 0.28–0.76 0.002 0.46 0.28–0.77 0.003
Surgery
   No 1 Ref 1 Ref
   Yes 0.86 0.64–1.16 0.34 0.92 0.65–1.31 0.66
Nutrition support
   No 1 Ref 1 Ref 1 Ref
   Yes 1.29 1.01–1.65 0.04 0.95 0.72–1.26 0.74 1.29 0.96–1.74 0.09
Hospitalized
   No 1 Ref 1 Ref 1 Ref 1 Ref
   Yes 1.65 1.28–2.12 <0.001 1.52 1.17–1.98 0.002 1.49 1.09–2.02 0.01 1.31 0.95–1.81 0.1
WBC count
   Normal 1 Ref 1 Ref 1 Ref 1 Ref
   Low 2.55 1.39–4.68 0.002 1.61 0.85–3.08 0.15 2.94 1.50–5.76 0.002 1.84 0.89–3.80 0.1
   High 2.04 1.47–2.82 <0.001 1.27 0.89–1.80 0.18 2.35 1.62–3.41 <0.001 1.36 0.90–2.06 0.14
Hemoglobin (g/dL)
   ≥12 1 Ref 1 Ref 1 Ref 1 Ref
   <12 2.38 1.86–3.06 <0.001 1.36 1.05–1.77 0.02 2.5 1.86–3.36 <0.001 1.05 0.75–1.47 0.78