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. 2021 May;9(10):892. doi: 10.21037/atm-21-2247

Table 2. Univariate and multivariate analysis of clinical factors on 1,083 samples with OS.

Characteristics Total (N) Univariate analysis Multivariate analysis
Hazard ratio (95% CI) P value Hazard ratio (95% CI) P value
Age (>60 vs. ≤60) 1,082 2.020 (1.465–2.784) <0.001 2.622 (1.709–4.023) <0.001
Race (White vs. Asian and Black or African American) 993 0.912 (0.615–1.350) 0.644
PAM50 (HER2, Basal and Lum B vs. Lum A) 1,042 1.576 (1.136–2.186) 0.006 1.495 (0.954–2.342) 0.080
T stage (T4 and T3 vs. T1and T2) 1,079 1.608 (1.110–2.329) 0.012 1.703 (1.030–2.816) 0.038
N stage (N3 vs. N0, N1, and N2) 1,063 2.767 (1.610–4.756) <0.001 2.886 (1.499–5.555) 0.002
Radiation therapy (yes vs. no) 986 0.576 (0.394–0.841) 0.004 0.605 (0.402–0.911) 0.016
TP53 (high vs. low) 1,082 1.360 (0.986–1.875) 0.061 1.002 (0.661–1.519) 0.994
PIK3CA (high vs. low) 1,082 1.258 (0.912–1.736) 0.162
MYC (high vs. low) 1,082 0.853 (0.620–1.173) 0.329
SLC7A5(high vs. low) 1,082 1.709 (1.234–2.367) 0.001 1.925 (1.202–3.083) 0.006

OS, overall survival; TP53, tumor protein p53; PIK3CA, phosphatidylinositol 3-kinases.