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. 2021 May;9(10):860. doi: 10.21037/atm-21-1908

Figure 1.

Figure 1

The expression of CircHIPK3 in normal and cancerous tissues of OSCC. (A) QRT-PCR is used to detect circHIPK3 expression in tumor and adjacent tissues. ***P<0.001; (B) QRT-PCR is used to detect HIPK3 expression in NOK and OSCC-15, Tca8113, SCC-9, SCC-25 and HSC-2. Compared with NOK group, *P<0.05, **P<0.01, ***P<0.001; (C,D) the stability of circHIPK3 in Tca8113 and SCC-9 cells is determined by the RNase R method. ***P<0.001; (E,F) the stability of circHIPK3 in Tca8113 and SCC-9 cells is detected by the actinomycin D method. *P<0.05, **P<0.01, ***P<0.001; (G) the survival curve of circHIPK3 in OSCC is obtained from the Kaplan-Meier Plotter library. circHIPK3, circular RNA HIPK3; OSCC, oral squamous cell carcinoma, QRT-PCR, quantitative real-time PCR.