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. 2021 May;9(10):860. doi: 10.21037/atm-21-1908

Figure 5.

Figure 5

CircHIPK3 promotes the expression of the NUPR1 and PI3K/AKT signaling pathways. (A) Western blot is used to detect expressions of NUPR1 in OSCC and normal tissues adjacent to cancer. ***P<0.001; (B) Pearson correlation analysis shows a correlation between CircHIPK3 and NUPR1 in OSCC tissue; (C,D) the expression of NUPR1 mRNA and protein is detected by QRT-PCR and Western blot. ***P<0.001; (E) the activation of PI3K/AKT is detected by Western blot. OSCC, oral squamous cell carcinoma. circHIPK3, circular RNA HIPK3; NUPR1, Nucleoprotein 1; OSCC, oral squamous cell carcinoma; QRT-PCR, quantitative real-time PCR.