Table 1. Pharmacokinetic parameters of HS-10296, HAS-719, and total radioactivity after dosing.
| Metabolite name | Tmax (h) | Cmax (ng/mL) | AUC0-t (h·ng/mL) | AUC0-∞ (h·ng/mL) | CL/F (L/h) | Vd/F (L) | t½ (h) |
|---|---|---|---|---|---|---|---|
| HS-10296 | 5.25±3.20 | 119±27.7 | 2,904±727 | 3,158±794 | 36.8±10.8 | 1,267±219 | 25.0±6.41 |
| HAS-719 | 6.50±2.52 | 22.2±3.94 | 1,027±121 | 1,117±103 | 99.1±8.92 | 5,965±724 | 41.8±3.93 |
| Total radioactivity | 4.00 | 479±43.1a | 76,718±46,938b | 235,209±194,880a | – | – | 863±930 |
a, ng Eq/g; b, h.ng Eq/g. Tmax, time of maximum concentration; Cmax, maximum concentration; AUC, area under curve; CL/F, apparent clearance; Vd/F, apparent volume of distribution; T1/2, half-life.