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mRNA relative expression ratio of OAT1/3 in the kidney and P-gp in the small intestine at 24 h after the administration of MTX with or without co-administration of (A) single-dose WZC and (B) multiple-dose WZC. *, P<0.05; **, P<0.01. MTX, methotrexate; WZC, Wuzhi capsule.
