Table 2.

Univariate and multivariate analysis of preoperative clinical and pathological features as prognostic factors for disease-free survival and disease-specific survival in the whole series

	Disease-free survival				Disease-specific survival
	Univariate	p Value	Multivariate	p Value	Univariate	p Value	Multivariate	p Value
Age, years
≤ 65	Ref.		Ref.		Ref.		Ref.
> 65	0.801 (0.527–1.216)	0.297	0.814 (0.533–1.243)	0.341	0.885 (0.534–1.469)	0.637	0.789 (0.471–1.322)	0.368
FIGO stage
IB2–IIB	Ref.		Ref.		Ref.		Ref.
III–IVA	1.652 (1.155–2.363)	0.006	1.398 (0.960–2.301)	0.081	1.878 (1.221–2.888)	0.004	1.1527 (0.983–2.372)	0.059
Lymph node status at imaging
Negative	Ref.		Ref.		Ref.		Ref.
Pelvic positive	1.404 (1.024–1.924)	0.035	1.309 (0.950–1.803)	0.100	1.283 (0.862–1.909)	0.219	1.122 (0.750–1.678)	0.576
Aortic ± pelvic positive	3.947 (2.201–7.078)	< 0.001	2.825 (1.554–5.138)	0.001	3.643 (1.802–7.367)	< 0.001	2.356 (1.149–4.830)	0.019
Histotype
Squamous	Ref.		Ref.		Ref.		Ref.
Other	1.223 (0.788–1.898)	0.370	1.070 (0.682–1.679)	0.767	1.184 (0.675–2.076)	0.555	1.075 (0.606–1.904)	0.804
Clinical response to CT/RT
Complete	Ref.		Ref.		Ref.		Ref.
Partial	2.352 (1.620–3.415)	< 0.001	2.149 (1.471–3.141)	< 0.001	3.327 (1.971–5.616)	< 0.001	3.005 (1.767–5.109)	< 0.001
Stable disease	7.228 (3.885–13.448)	< 0.001	6.053 (3.186–11.499)	< 0.001	12.475 (5.830–26.695)	< 0.001	9.980 (4.543–21.921)	< 0.001

Bold values indicate statistically significant

CT/RT chemoradiotherapy, O-RS open radical surgery, MI-RS minimally invasive radical surgery