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. Author manuscript; available in PMC: 2022 Jul 9.
Published in final edited form as: J Mol Biol. 2021 Feb 20;433(14):166883. doi: 10.1016/j.jmb.2021.166883

Fig. 1. Simplified model of enhancer-core promoter interactions.

Fig. 1.

Enhancers contain specific sequence motifs that are bound by TFs . They activate core promoters by regulating promoter/enhancer interactions, PIC assembly, and Pol II recruitment through a wide variety of cofactors.