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. Author manuscript; available in PMC: 2022 Jul 9.
Published in final edited form as: J Mol Biol. 2021 Feb 25;433(14):166897. doi: 10.1016/j.jmb.2021.166897

Figure 2: Spt5 DNA and RNA clamps.

Figure 2:

A) Superimposed structures of the Spt5 nucleic acid clamps in their paused (grey, PDB ID: 6GML) and active (orange, PDB ID: 6GMH). The KOW1 and KOW4 domains change conformation upon pause release, resulting in clamp opening. B) Surface model of Pol II-DSIF. The Spt5 NGN and KOW1 domains (shown in orange) form a clamp around the upstream DNA (purple) and the Spt5 KOW4 and KOW5 domains (orange) form a clamp around the nascent RNA (blue). PDB ID: 6GML.