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. Author manuscript; available in PMC: 2022 Jul 9.
Published in final edited form as: J Mol Biol. 2021 Feb 25;433(14):166897. doi: 10.1016/j.jmb.2021.166897

Figure 4: Conserved Spt5 and NELF P-TEFb phosphorylation sites.

Figure 4:

Ten of the residues identified as putative P-TEFb phosphorylation sites on human Spt5 are conserved or semi-conserved (Ser or Thr) in Drosophila Spt5. In contrast, only one putative NELF-A phosphorylation site is semi-conserved from human to Drosophila and three putative NELF-E phosphorylation sites are conserved from human to Drosophila. The S666 and T806 in Spt5 (red) have been identified as critical participants in the phosphatase-kinase switch that governs pausing and pause release dynamics[78]; both residues are conserved in Drosophila.