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. Author manuscript; available in PMC: 2022 Jul 9.
Published in final edited form as: J Mol Biol. 2021 Mar 5;433(14):166912. doi: 10.1016/j.jmb.2021.166912

Figure 3:

Figure 3:

Cross-talks of the identities and PTMs of the 7th residues with Tyr1. (a) The conserved active sites of c-Abl and ABL2 show a highly positively charged pocket close to the reaction center. Modeling reveals close proximity of the pocket with the binding site of the 7th residue from the previous repeat. (b) A schematic model of how citrullination of Arg1810 promotes transcription elongation. (c) Favorable electrostatic interactions between the CTD and c-Abl when the 7th residue has a negatively-charged side chain such as glutamate.