FIGURE 1.

Wogonin treatment improves the prognosis of mice with LPS‐ or CLP‐induced sepsis. A, Schematic presentation of the establishment of LPS‐ and CLP‐induced sepsis mouse model. B and C, Body temperature and respiratory rate changes 1 h before and 8 h after LPS injection or 2 h before and 12 h after CLP operation in sepsis mouse model (n = 6, respectively). D, Detection of serum TNF‐α, IL‐1β, IFN‐γ and IL‐6 in LPS‐ and CLP‐induced sepsis mice (n = 6). E and F, Body temperature and respiratory rate changes after wogonin treatment in LPS‐ and CLP‐induced sepsis mice (n = 6). G, Detection of serum TNF‐α, IL‐1β, IFN‐γ and IL‐6 after wogonin treatment in LPS‐ and CLP‐induced sepsis mice (n = 6). H, Survival analysis of LPS‐ and CLP‐induced sepsis mice (n = 7) with or without wogonin treatment. The concentration of wogonin was 50.0 mg/kg. The results are presented as mean ± SD through at least 3 independent experiments and were analysed by one‐way analysis of variance (ANOVA). The results of survival comparison were analysed by Kaplan‐Meier survival curves and log‐rank test (Mantel‐Cox method). *P < .05, **P < .01, ***P < .001, ****P < .0001