TABLE 2.
KEGG pathways most significantly enriched with down‐regulated SCGs
| Pathway | KEGG ID | P | BH.adj.P | Genes in pathway | SCGs in pathway | Gene symbols of SCGs in pathway |
|---|---|---|---|---|---|---|
| Protein digestion and absorption | hsa04974 | 5.33 × 10−7 | 1.51 × 10−5 | 61 | 8 | ATP1A2, COL25A1, COL2A1, COL4A6, COL6A3, COL9A3, SLC8A1, SLC8A3 |
| Cell adhesion molecules | hsa04514 | 6.77 × 10−7 | 1.78x × 10−5 | 101 | 10 | CADM1, CD274, CDH2, CNTNAP2, LRRC4C, NCAM1, NLGN1, NLGN4X, NRXN1, NRXN3 |
| Neuroactive ligand‐receptor interaction | hsa04080 | 1.46 × 10−6 | 3.56 × 10−5 | 109 | 10 | CHRM4, DRD1, GABBR2, GRIA3, GRIA4, GRID2, GRIK1, GRM1, HTR2A, OXTR |
| Calcium signalling pathway | hsa04020 | 4.95 × 10−6 | .000113 | 148 | 11 | CAMK4, DRD1, GRM1, HTR2A, MYLK4, NTRK3, OXTR, PDE1A, SLC8A1, SLC8A3, TRDN |
| Glutamatergic synapse | hsa04724 | 7.43 × 10−6 | .000158 | 83 | 8 | ADCY5, DLGAP1, GRIA3, GRIA4, GRIK1, GRM1, KCNJ3, SLC38A1 |
| Morphine addiction | hsa05032 | 1.05 × 10−5 | .000208 | 66 | 7 | ADCY5, DRD1, GABBR2, KCNJ3, PDE11A, PDE1A, PDE4D |
| Amphetamine addiction | hsa05031 | 1.10 × 10−5 | .000208 | 48 | 6 | ADCY5, CAMK4, DRD1, GRIA3, GRIA4, PPP1R1B |
| cAMP signalling pathway | hsa04024 | 1.67 × 10−5 | .000299 | 140 | 10 | ADCY5, ATP1A2, CAMK4, DRD1, GABBR2, GRIA3, GRIA4, OXTR, PDE4D, PPP1R1B |
| Gap junction | hsa04540 | 2.72 × 10−5 | .000464 | 75 | 7 | ADCY5, DRD1, GRM1, GUCY1A2, HTR2A, PRKG1, TUBB2B |