FIGURE 5.

Molecular function and characteristics of LEPR in TAO. (A‐B) Gene set enrichment analysis (GSEA) showed (A) MHC protein complex and MHC class II protein complex in GO processes and (B) antigen processing and presentation pathway, complement and coagulation cascade pathway together with type 1 diabetes mellitus pathways among Kyoto Encyclopedia of Genes and Genomes (KEGG) pathways were obviously enriched in TAO patients with up‐regulated LEPR gene. (C) Forest plots of mean difference showed leptin signalling pathway–related gene differences between TAO and GD group. (D) The correlations of the expression of the differentially expressed genes in leptin signalling pathway with LEPR expression in TAO vs GD set. GD, Graves’ disease; HC, healthy control; TAO, thyroid‐associated ophthalmopathy