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. 2021 Jun 7;12(6):587. doi: 10.1038/s41419-021-03858-7

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 2 — A DGCR5 expression on ESCC cells (Eca9706, TE1, Yes-2, Kyse150, and Kyse170) was examined by qRT-PCR. B qRT-PCR analysis for expression levels of DGCR5 on TE1 and Kyse170 cells after transduction with siRNA-DGCR5. C Cell proliferation analysis was performed with CCK-8 assays. Cell viabilities were measured at five different time points. D DGCR5 knockdown remarkably inhibited cell proliferation by colony formation. E, F Verification of DGCR5 knockout affects the apoptosis on ESCC cells by FACS and western blot. G DGCR5 knockdown inhibited cell migration and invasion by transwell migration and invasion assays. *P < 0.05 and **P < 0.01.