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. 2021 Jun 7;12(6):587. doi: 10.1038/s41419-021-03858-7

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 4 — A Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway of DGCR5‑related ESCC genes. Fisher exact P values were plotted for each enriched functional category. Enriched functional categories with P < 0.05 are shown. B GESA enrichment of the subsets of DGCR5‑related genes involved in apoptosis. C Mcl-1mRNA was upregulated in ESCC tissues according to the TCGA database. D Mcl-1 mRNA was increased in the 70 pairs of ESCC samples. E Mcl-1 mRNA was inhibited when DGCR5 knockdown in TE1 and Kyse170 cells. F Mcl-1 mRNA was upregulated when DGCR5 overexpressed in TE1 and Kyse170 cells. G Knockdown of DGCR5 promoted cell apoptosis while Mcl-1 overexpression inhibited apoptosis in TE1 and Kyse170 cells, but simultaneous knockdown DGCR5 and Mcl-1 overexpression could reverse it. *P < 0.05 and **P < 0.01.