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. 2021 Jun 7;12:3367. doi: 10.1038/s41467-021-23637-4

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 7 — a Boxplots showing RDM15 protein enrichment in RDM15-dependent siRNA regions. PoI IV-only siRNA regions, which were not affected in rdm15, served as the control. In the boxplots, the center is the median of the data; upper bound of the box is an upper hinge, 75% quantile of the data; lower bound of the box is a lower hinge, 25% quantile of the data; minima is the smallest data point greater than or equal to lower hinge − 1.5 x interquartile range (IQR); maxima is the largest data point less than or equal to upper hinge + 1.5 x IQR. b Correlation of the change of siRNA accumulation (WT vs. rdm15) with RDM15 enrichment. RDM15-dependent siRNA regions were ranked by the change of siRNAs (WT vs. rdm15). c Correlation of the change of siRNA accumulation (WT vs. rdm15) with H3K4me1 enrichment. RDM15-dependent siRNA regions were ranked by the change of siRNAs (WT vs. rdm15). d IGB display of RDM15 and H3K4me1 protein enrichment and DNA methylation levels at several RDM15 binding targets.