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. 2021 Jan 18;28(6):1837–1848. doi: 10.1038/s41418-020-00710-x

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© The Author(s), under exclusive licence to ADMC Associazione Differenziamento e Morte Cellulare 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 1 — A Western blot analysis showing the effect of MITF downregulation on ubiquitination in cytoplasmic/membrane and nuclear protein fractions in SKmel28 cells (left panel) and 501Mel cells (right panel). B Kaplan–Meier survival curve of cutaneous melanoma patients with low (black line) or high (red line) expression level of FBXO32 from GSE19234 dataset. C FBXO32 expression in human naevi (n = 18), dysplastic naevi (n = 11), primary melanomas (n = 23), and metastatic melanomas (n = 5) (GSE12391).