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. 2021 Jan 18;28(6):1837–1848. doi: 10.1038/s41418-020-00710-x

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© The Author(s), under exclusive licence to ADMC Associazione Differenziamento e Morte Cellulare 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 5 — A Heat map showing the top 50 genes significantly affected by FBXO32 knockdown in melanoma cells from patient 2, 501Mel, SKmel28, and WM9 cell lines. B Western blot analysis of CDK6 expression after transfection of siRNAs targeting FBXO32 (left panel) or transduction by FBXO32-expressing lentivirus (right panel) in 501Mel cells. HSP90 was probed as loading control. C CDK6 expression after siRNAs transfection targeting CDK6 in 501Mel transduced with (right panel) or without (left panel) FBXO32 lentivirus. D Representative image of the effect of CDK6 downregulation on migration of 501Mel cells overexpressing (lower panel) or not (upper panel), FBXO32. Bar = 100 µm. E Effect of CDK6 downregulation on colony formation in 501Mel and A375 cells overexpressing, or not, FBXO32.