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. 2021 Jan 18;28(6):1837–1848. doi: 10.1038/s41418-020-00710-x

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© The Author(s), under exclusive licence to ADMC Associazione Differenziamento e Morte Cellulare 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 6 — A Co-immunoprecipitation and western blot analysis showing interaction between FBXO32 with BRG1 and BAF60a in SKmel28 transduced with Myc/DDK-tagged FBXO32 vector. B Immunofluorescence labeling of FBXO32 (green) and BRG1 (red) in isolated melanoma cells from patient 2. The photos taken by the confocal microscopy show a colocalization of the two proteins in the nucleus. Bar = 5 µm. C UCSC capture of HDAC3 locus showing BRG1-binding site (upper panel) overlapping H3K4me3 active mark (lower panel). D UCSC capture of CDK6 locus showing BRG1 binding site (upper panel) overlapping H3K4me3 active mark (lower panel). E, F ChIP-qPCR analysis in parental and FBXO32 overexpressing 501Mel cells, after immunoprecipitation with DDK antibody. DNA was amplified either with HDAC3 promoter primers (E) or CDK6 promoter primers (F) (mean ± SD, n = 3).