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. 2021 Jun 7;11:11998. doi: 10.1038/s41598-021-91585-6

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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ORF8 protein and its interaction with MHC-I. (A) Shows the position of each mutation observed in the SARS-CoV-2 genomes isolated from different regions. The ORF8 structure is shown as cartoon, and the amino acid positions are shown as mesh. (B) The most stable conformation of the ORF8:MHC-I complex predicted by the HADDOCK program. MHC-I and ORF8 are shown as cartoon and colored in light blue and gray, respectively. The region from Y73 to V81 is shown as mesh, to highlight where the viral protein is recognized by the host. It is important to observe that mutations in these regions could directly impact on protein–protein interactions.