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. 2021 Jun 7;12:3337. doi: 10.1038/s41467-021-23630-x

Fig. 8. Hierarchy of transcription factor binding.

Fig. 8

SPFs engage their target sequences in closed chromatin and in the presence of DNA methylation. Upon binding, most SPFs drive DNA demethylation through active processes, mainly mediated by the TET enzymes, while SOX2 leads to passive DNA demethylation. Loss of DNA methylation allows the binding of methylation-sensitive PFs. Nucleosome remodelling and deposition of histone modifications associated with open chromatin regions, mediated by both SPFs and PFs, create a favourable environment for the binding of settler TFs.