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. 2021 Jun 7;12(6):586. doi: 10.1038/s41419-021-03875-6

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 1 — A Immunofluorescence staining of HA (red) and I-α-I HC1 (green) in cancer tissues and corresponding adjacent normal tissues from patients with early (stage I, n = 7) or late (stage III, n = 9) staged breast cancer, normal mammary gland tissues from FVB mice, and cancer tissues from MMTV-PyMT mice with early (week 10) or late (week 16) staged breast cancer. B Immunofluorescence staining of HA (red) and I-α-I HC2 (green) in corresponding tissues. The white arrowheads refer to the co-localization of HA and I-α-I, which means HA cross-linking. HA and I-α-I HCs were both localized within and outside of cells. C The intensity ratio of HA co-localized with I-α-I HCs to total HA was used to determine the levels of HA-HC complexes. The intensity percentage of HA-HCs co-localization was acquired by the Image J software. Error bars show mean ± SD values. Statistical analysis was performed using Student’s t test. *p < 0.05, **p < 0.01, ***p < 0.001.