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. 2021 Jun 7;12:3355. doi: 10.1038/s41467-021-23661-4

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 4 — Kaplan–Meier (KM) plot for OS for triple-negative breast cancer (TNBC) patients of European ancestry treated with atezolizumab plus nab-paclitaxel (top) and placebo plus nab-paclitaxel (bottom) from IMpassion130. Patients were split into two groups on the basis of median split of the hypothyroidism PRS (hypoT) across all European ancestry IMpassion130 patients with germline genetic data. Censoring events are denoted by vertical dashes. Dashed horizontal and vertical lines designate the median survival time. Shaded regions provide the 95% confidence intervals. impas130 = IMpassion130. A = atezolizumab; NabP = Nab-paclitaxel.